Statut : Chargé de recherche, CNRS
Contact : paul.verdu[@]mnhn.fr
tel : +33 1 44 05 73 17
Équipe de recherche :
Anthropologie évolutive
Co-coordinateur du plateau technique "Paléogénomique et génétique moléculaire" P2GM du MNHN au Musée de l’Homme
Résumé
2015-présent : Co-coordinateur du plateau technique "Paléogénomique et génétique moléculaire" P2GM du MNHN au Musée de l’Homme
2012-présent : Chercheur CNRS de l’UMR7206
2011-2012 : Post Doctorat à Stanford University (Department of Biology, supervisor : Noah A. Rosenberg)
2009-2011 : Post Doctorat à University of Michigan (Medical School, supervisor : Noah A. Rosenberg)
2005-2009 : Thèse de doctorat en Anthropologie Biologique et Génétique des Populations Humaines délivrée en janvier 2009 par l’Université Pierre et Marie Curie et le Muséum National d’Histoire Naturelle. Dir. : Evelyne Heyer. Titre : Anthropologie Génétique des Populations Humaines d’Afrique Centrale : Histoire du Peuplement Pygmée
2004-2005 : Master 2 de Génétique Humaine de l’Université Pierre et Marie Curie
2001-2005 : Diplôme d’Ingénieur Agronome de l’AgroParisTech (anciennement INA P-G)
1998-2001 : Classe Préparatoire Biologie, Chimie, Physique et Sciences de la Terre (Lycée Saint Louis, Paris)
Main Research Areas
Anthropological Genetics
Population Genetics
Anthropology
Research focus
Peopling and demographic histories of modern human populations
Sociocultural behaviours and human genetic diversity
Human biological adaptation
Admixture histories and human cultural and genetic diversity
Demographic inference with Approximate Bayesian Computation
Mathematical modelling of complex admixture processes
Main Projects and Collaborations
METHIS : Influence of admixture histories on the genetic evolution of hybrid populations
Funding 2015-2019 : ANR-15-CE32-0009-01
- Mathematical modelling of complex admixture histories
- Collaborator : Noah A. Rosenberg (Stanford University)
- Approximate Bayesian Computation methods for reconstructing complex admixture histories using genetic data
- Collaborators : Erkan Buzbas (University of Idaho) ; Frédéric Austerlitz (CNRS UMR7206)
Reconstructing the linguistic and genetic history of admixture in Cape Verdean Kriolu speaking populations
- Collaborators : Marlyse Baptista (University of Michigan) ; Noah A. Rosenberg and Ethan M. Jewett (Stanford University) ; Trevor J. Pemberton (University of Manitoba)
- Collaborators : Erkan Buzbas (University of Idaho) ; Frédéric Austerlitz (CNRS UMR7206)
- Assortative mating, admixture-related natural selection and hybrid fitness in a re-introduced hybrid population of santworth (Arenaria grandiflora) : implications for bio-diversity conservation strategies
- Collaborators : Nathalie Machon (MNHN Paris)
- History of admixture and patterns of population structure in First Nation Populations of Northwest North America
- Collaborators : Ripan S. Malhi (University of Illinois Urbana-Champaign) ; Noah A. Rosenberg (Stanford University) ; Trevor J. Pemberton (University of Manitoba)
Origins, migrations and differential adaptation of Central African Pygmy and non-Pygmy populations
- Central African peopling history : Origins and past demography of Pygmy and neighboring non-Pygmy populations
- Sociocultural interactions and admixture patterns among Central African Pygmy and neighbouring non-Pygmy populations
- Collaborators : Frédéric Austerlitz, Evelyne Heyer, Myriam Georges, Sylvie Le Bomin, Marie-France Mifune, Serge Bahuchet (CNRS-MNHN UMR7206) ; Alain Froment (IRD) ; Barry S. Hewlett (Washington State University) ; Arnaud Estoup, Renaud Vitalis, Raphaël Leblois (CBGP/INRA, Montpellier) ; Etienne Patin, Lluis Quintana-Murci (Institut Pasteur) ; Mattias Jakobsson, Carina Schelbusch (Uppsala University)
- Influence of the last climatic crisis (4,000 years before present) on Central African populations migrations and dispersal behaviours.
- Collaborators : Anne-Marie Lézine (Université Pierre et Marie Curie) ; Doyle McKey (Université Montpellier 2)
- Genetic determination and differential evolution of Central African Pygmy and non-Pygmy adult height
- Collaborators : Alain Froment (IRD) ; Noémie S.A. Becker (LMU) ; Trevor J. Pemberton (University of Manitoba) ; Noah A. Rosenberg (Stanford University) ;Barry S. Hewlett (Washington State University)
Publications
-------------
2018
29. Lopez M*, Kousathanas A*, Quach H, Harmant C, Mouguiama-Daouda P, Hombert J-M, Froment A, Perry G.H., Barreiro L.B., Verdu P, Patin E and Quintana-Murci LL (2018)
The demographic history and mutational load of African hunter-gatherers and farmers
Nature ecology & evolution 2 (4), 721
Article
28. Buzbas EO, Verdu P (2018)
Inference on admixture fractions in a mechanistic model of recurrent admixture
Theoretical Population Biology Available online 28 March 2018
Article
-------------
2017
27. Thouzeau V, Mennecier P, Verdu P*, Austerlitz F* (2017) * equal supervisors
Genetic and linguistic histories in Central Asia inferred using Approximate Bayesian computations
Proceedings of the Royal Society B online August 2017
Article
26. Verdu P*, Jewett EM*, Pemberton TJ, Rosenberg NA** and Baptista M** (2017) * equal contributors,** equal supervisors
Parallel Trajectories of Genetic and Linguistic Admixture in a Genetically Admixed Creole Population
Current Biology Vol 27, Issue 16, pp. 2529–2535
Abstract
25. Patin E*, Lopez M, Grollemund R, Verdu P,
Harmant C, Quach H, Laval G, Perry GH, Barreiro LB, Froment A, Heyer E, Massougbodji A, Fortes-Lima C, Migot-Nabias F, Bellis G, Dugoujon J-M, Pereira JB, Fernandes V, Pereira L, Van der Veen L, Mouguiama-Daouda P, Bustamante CD, Hombert JM, Quintana-Murci Ll* (2017) * equal contributors
Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America
Science 356, 543–546
Article
24. George H Perry and Verdu P (2017)
Genomic perspectives on the history and evolutionary ecology of tropical rainforest occupation by humans.
Quaternary International 448, 150-157.
Article
-------------
2016
23. Verdu P (Accepted 2015)
Sociocultural behaviors and human genetic diversity.
in International Encyclopedia of Anthropology, Wiley Publishing Group (Cambridge, UK).
22. Verdu P (2016)
African Pygmies
Current Biology Jan 11 ;26(1):R12-4. doi:0.1016/j.cub.2015.10.023.
QuickGuide
-------------
2015
21. Ségurel L and Verdu P (2015)
Peut−on voir nos différences génétiques ?
in Une Belle Histoire de l’Homme, Ed. Evelyne Heyer ; Flammarion−MNHN, p. 24−26
Flammarion
20. Verdu P and Bahuchet S (2015)
Comments on "Middle to Late Holocene Paleoclimatic Change and the Early Bantu Expansion in the Rain Forests of Western Central Africa" by K Bostoen, et al.
Current Anthropology 56 (3), 354−384
Abstract
19. Verdu P and Austerlitz F (2015)
Post marital residence behaviours shape genetic variation in hunter−gatherer and agricultural populations from Central Africa.
Hunter Gatherer Research 1 (1), 107−124
Abstract
-------------
2014
18. Goldberg A, Verdu P, and Rosenberg NA. (2014)
Autosomal admixture levels are informative about sex bias in admixed
populations.
Genetics 198 (3), 1209−1229.
Abstract
17. Verdu P, Pemberton TJ, Laurent R, Kemp BM, Gonzalez-Oliver A, Gorodezky C, Hughes CE, Shattuck MR, Petzelt B, Mitchell J, Harry H, William T, Worl R, Cybulski JS, Rosenberg NA, and Malhi RS. (2014)
Patterns of admixture and population structure in native populations of northwest North America.
Plos Genetics 10(8):e1004530. doi : 0.1371/journal.pgen.1004530. eCollection 2014.
Abstract
16. Patin E, Siddle KJ, Laval G, Quach H, Harmant C, Becker N, Froment A, Régnault B, Lemée L, Gravel S, Hombert JM, Van der Veen L, Dominy NJ, Perry GH, Barreiro LB, Verdu P, Heyer E, and Quintana-Murci L (2014)
The impact of agricultural emergence on the genetic history of African rainforest hunter-gatherers and agriculturalists.
Nature Communications 5:3163. doi : 10.1038/ncomms4163
Abstract
15. Aimé C, Verdu P, Ségurel L, Martinez-Cruz B, Hegay T, Heyer E, and Austerlitz F (2014)
Microsatellite data show recent demographic expansions in sedentary but not in nomadic human populations in Africa and Eurasia.
European Journal of Human Genetics doi : 10.1038/ejhg.2014.2
Abstract
14. Verdu P (2014)
Population Genetics of Central African Pygmies and non-Pygmies.
in Hunter-Gatherers of the Congo Basin : Culture, History and Biology of African Pygmies ; Ed. Barry S. Hewlett, Transaction Publishers, New Brunswick (New Jersey)
[Transaction]
-------------
2013
13. Aimé C, Laval G, Patin E, Verdu P, Segurel L, Chaix R, Hegay T, Quintana-Murci L, Heyer E, and Austerlitz F (2013)
Human Genetic Data Reveal Contrasting Demographic Patterns between Sedentary and Nomadic Populations That Predate the Emergence of Farming.
Molecular Biology and Evolution 30(12):2629-44
[PDF] Abstract
12. Verdu P, Becker NS, Froment A, Georges M, Grugni V, Quintana-Murci L, Hombert JM, Van der Veen L, Le Bomin S, Bahuchet S, Heyer E, and Austerlitz F (2013)
Sociocultural behavior, sex-biased admixture, and effective population sizes in Central African Pygmies and non-Pygmies.
Molecular Biology and Evolution 30(4):918-937
[PDF] Abstract
11. Verdu P (2013)
Perspectives de la génétique humaine sur l’origine et la diversité des populations pygmées d’Afrique centrale.
Journal des Africanistes Tome 82 - Fascicule 1-2 pp. 53-72
Abstract
10. Becker NS, Verdu P, Georges M, Duquesnoy P, Froment A, Amselem S, Le Bouc Y, and Heyer E (2013)
The role of GHR and IGF1 genes in the genetic determination of African pygmies’ short stature.
European Journal of Human Genetics 21(6):653-658
[PDF] Abstract
-------------
2012
9. Verdu P and Destro-Bisol G (2012)
African Pygmies, what’s behind a name ?
Human Biology 84(1):1-10
[PDF]
-------------
2011
8. Verdu P and Rosenberg NA (2011)
A general mechanistic model for admixture histories of hybrid populations.
Genetics 189(4):1413-1426.
[PDF] Abstract
7. Becker NS*, Verdu P*, Froment A, Le Bomin S, Pagezy H, Bahuchet S, and Heyer E (2011) * equal contributors
Indirect evidence for the genetic determination of short stature in African Pygmies.
American Journal of Physical Anthropology 145(3):390-401
[PDF] Abstract
-------------
2010
6. Verdu P, Leblois R, Froment A, Thery S, Bahuchet S, Rousset F, Heyer E, and Vitalis R (2010)
Limited dispersal in mobile hunter-gatherer Baka Pygmies.
Biology Letters 6(6):858-861
[PDF] Abstract
5. Becker NS*, Verdu P*, Hewlett B*, and Pavard S* (2010) * equal contributors
Can life history trade-offs explain the evolution of short stature in human pygmies ? A response to Migliano et al. (2007).
Human Biology 82(1):17-27
[PDF] Abstract
-------------
2009
4. Verdu P, Austerlitz F, Estoup A, Vitalis R, Georges M, Thery S, Froment A, Le Bomin S, Gessain A, Hombert JM, Van der Veen L, Quintana-Murci L, Bahuchet S, and Heyer E (2009)
Origins and genetic diversity of pygmy hunter-gatherers from Western Central Africa.
Current Biology 19(4):312-318
[PDF] Abstract
-------------
2008
3. Quintana-Murci L, Quach H, Harmant C, Luca F, Massonnet B, Patin E, Sica L, Mouguiama-Daouda P, Comas D, Tzur S, Balanovsky O, Kidd KK, Kidd JR, van der Veen L, Hombert JM, Gessain A, Verdu P, Froment A, Bahuchet S, Heyer E, Dausset J, Salas A, and Behar DM (2008)
Maternal traces of deep common ancestry and asymmetric gene flow between Pygmy hunter-gatherers and Bantu-speaking farmers.
Proceedings of the National Academy of Sciences 105(5):1596-1601
[PDF] Abstract
-------------
2006
2. Verdu P*, Barreiro LB*, Patin E, Gessain A, Cassar O, Kidd JR, Kidd KK, Behar DM, Froment A, Heyer E, Sica L, Casanova JL, Abel L, and Quintana-Murci L (2006) * equal contributors
Evolutionary insights into the high worldwide prevalence of MBL2 deficiency alleles.
Human Molecular Genetics 15(17):2650-2658.
[PDF] Abstract
-------------
2005
1. Kim JJ, Verdu P, Pakstis AJ, Speed WC, Kidd JR, and Kidd KK (2005)
Use of autosomal loci for clustering individuals and populations of East Asian origin.
Human Genetics 117(6):511-519.
[PDF] Abstract